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Synthesis 2009(18): 3039-3046
DOI: 10.1055/s-0029-1216893
DOI: 10.1055/s-0029-1216893
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkA Facile Synthetic Method for Fluorine-Containing 1,7-Phenanthrolines: Pyridine-Ring Formation Reaction of N-Propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with Various Nucleophiles
Further Information
Received
25 March 2009
Publication Date:
10 July 2009 (online)
Publication History
Publication Date:
10 July 2009 (online)
Abstract
Novel fluorine-containing 1,7-phenanthrolines with a variety of substituents at the 3-position were easily synthesized in moderate to high yields by the pyridine-ring formation reaction of N-propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with various amines, thiols, alcohols, and phenols.
Key words
1,7-phenanthrolines - fluorine - pyridine-ring formation - propargylamines - 5-quinolines
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